Port St. Lucie is a city in St. Lucie County, Florida.
In 2009 the State of Florida estimated the City's population at 155,251. Port St. Lucie forms part of a metropolitan area called the Port St. Lucie, Florida Metropolitan Statistical Area that in 2009 was estimated to have 406,296 residents.
In the early years, Port Saint Lucie was a largely uninhabited tract of land south of White City, Florida, composed of a fishing camp, a few farms and businesses near US1. In 1958, with a budget of $50 million, the General Development Corporation (GDC) purchased the River Park development and 40,000 acres along the North Fork of the St. Lucie River. In 1959, the GDC opened its first bridge over the St. Lucie River, allowing for direct automobile access to Port St. Lucie.